The Tongue Drive System is a novel technology that empowers people with disability to achieve maximum independence at home and in the community by enabling them to drive a power wheelchair and control their environment in a smoother and more intuitive way. This study is the first to show that the wireless and wearable Tongue Drive System outperforms sip-and-puff in controlling wheelchairs. Sip-and-puff is the most popular assistive technology for controlling a wheelchair. The Tongue Drive System is controlled by the position of the user’s tongue. A magnetic tongue stud lets them use their tongue as a joystick to drive the wheelchair. Sensors in the tongue stud relay the tongue’s position to a headset, which then executes up to six commands based on the tongue position. Individuals with paralysis were able to use a tongue-controlled technology to access computers and execute commands for their wheelchairs at speeds that were significantly faster than those recorded in sip-and-puff wheelchairs, but with equal accuracy. The Tongue Drive System holds promise for patients who have lost the use of their arms and legs, a condition known as tetraplegia or quadriplegia.